When GIR forgets to close Zim's front door one night, Dib sneaks inside Zim's base, takes a picture of him without his disguise on and escapes before the alien could catch him. Once at home, Dib inserts the picture on a floppy disk and places it inside an envelope, intending to send it to "Mysterious Mysteries of Strange Mystery", in order to prove that aliens exist. Little does he know that Zim formulated a plan to shrink himself down to microscopic size to invade Dib's body via a microscopic submarine. Once inside, he accesses Dib's nervous system, giving him control of Dib's arms and, as a result, making him crush the floppy disk. When Dib tells him that he has a copy of the disk hidden in his house, Zim attempts to travel to Dib's brain and perform a brain wipe, to stop him remembering where he hid the disk copy.
Fortunately for Dib, his father has been working on some technology that may just help Dib stop Zim before it's too late: another microscopic submarine, with videogame-like control. However, Dib has to be careful, because he's extremely vulnerable due to Zim being inside him. When Gaz mistakes Dib's efforts to defend himself from Zim for a video game, she gets excited and asks Dib to let her play. Unfortunately, Zim manages to attack Dib's brain, making Dib forget where the disk is hidden.
Zim also attacks Dib's nerves, making him twitch, speak, and move erratically, so Gaz takes his place and begins to play what she thinks is a video game. Being a highly experienced gamer, she defeats Zim very quickly, inserts her name in a High Score screen and walks away. To add insult to injury, Dib ends the battle by literally flushing Zim from his system.
End of Spoilers:There is no further spoilers for this section or article. You can breathe now.
The show Mysterious Mysteries is a parody of Unsolved Mysteries, which is a real show that deals with the unknown and paranormal. Also, the TV show itself makes its first appearance.
Some sound effects are taken from Star Trek VI: The Undiscovered Country and Star Trek: Deep Space Nine.
This episode marks the first time Dib has seen Zim without his disguise.
This is also the first time Zim is seen without his PAK.
A former game, titled Dib's Nanochase was once a game on Nickelodeon's official website, based on this episode.
The title returned with the squiggly Invader ZIM font instead of the official, being the fourth episode to follow this trend.
This episode marks the third episode that Dib and Gaz had a speaking role.
This episode was originally going to be aired with Germs, but Bestest Friend and Dark Harvest were considered to be "too twisted" to be aired together. Though, they can both be considered to be really dark episodes.
In this episode, Zim said he has been driving ships before Dib was born, so this means Zim, in both Earth and Irken years, is older than Dib.
When Mysterious Mysteries shows the alien in the envelope, the shapes in the background are identical to the ones used on Zim's House's wallpaper.
When Zim is about to make Dib "not smart no more" you can see three choices on his screen. 'Just a Bit', 'A Lot', and the one Zim chooses is 'Maximum'.
When Professor Membrane zaps something with a soldering iron from the ceiling array of tools he uses, before Dib asks for his help, you can see him lift up a smoldering fork.
There is a Professor Membrane mask next to the TV and a costume behind the couch. This appears again in later episodes.
When Gaz is watching Dib pilot the nanoship, she opens her eyes and has blue eyes, instead of the original brown eyes. This is in reference to the Pilot, where the same thing is done but in reverse.
When Zim's robot was hitting Dib the armor was stuck on 70%. When Zim was hitting Dib's nanoship again the armor said 42%, then 33%, then 42%.
In the scenes with Zim inside of Dib, Zim's colors are switched around, in which his skin turns pink and his eyes turn green; this gets fixed right when Zim explains his plan to Dib on the television. It could, however, just be how Zim is lit in the ship. This also happens in the Pilot as another goof.
A small goof can be seen: when Dib writes on the envelope, it says "...Strange Mysteries"; when he inserts the cassette, it is the shows' correct title--"...Strange Mystery"
A flashback shows Dib eating peas when Zim enters his body when Zim explains how he got into his body. When he first said it, he didn't have peas on his plate, but instead was eating mashed potatoes when he said the lines "Yeah, sick with fear!".
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